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Bargonetti, Jill

One or more keywords matched the following items that are connected to Bargonetti, Jill

Item Type	Name
Grant	The Role of the Mutant p53-PARP-MCM Pathway in Triple Negative Breast Cancer
Academic Article	p53 binds to a constitutively nucleosome free region of the mdm2 gene.
Academic Article	DNA adducts of decarbamoyl mitomycin C efficiently kill cells without wild-type p53 resulting from proteasome-mediated degradation of checkpoint protein 1.
Academic Article	A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation.
Academic Article	A DNA damage signal is required for p53 to activate gadd45.
Academic Article	8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers.
Academic Article	Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy.
Academic Article	Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway.
Academic Article	Site-specific binding of wild-type p53 to cellular DNA is inhibited by SV40 T antigen and mutant p53.
Academic Article	C. elegans CEP-1/p53 and BEC-1 are involved in DNA repair.
Academic Article	Initiation of rolling-circle replication in pT181 plasmid: initiator protein enhances cruciform extrusion at the origin.
Academic Article	Decarbamoyl mitomycin C (DMC) activates p53-independent ataxia telangiectasia and rad3 related protein (ATR) chromatin eviction.
Academic Article	Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells.
Academic Article	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.
Academic Article	Impedimetric detection of mutant p53 biomarker-driven metastatic breast cancers under hyposmotic pressure.
Academic Article	Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4.
Academic Article	Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.
Academic Article	Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient.
Academic Article	Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway.
Academic Article	DNA-binding properties of the p53 tumor suppressor protein.
Academic Article	p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.
Academic Article	MDM2, MDM2-C, and mutant p53 expression influence breast cancer survival in a multiethnic population.
Academic Article	Measurement of gene expression by translational coupling: effect of copy mutations on pT181 initiator synthesis.
Academic Article	A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.
Academic Article	Context-dependent roles of MDMX (MDM4) and MDM2 in breast cancer proliferation and circulating tumor cells.
Academic Article	The p53 protein is an unusually shaped tetramer that binds directly to DNA.
Academic Article	Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer.
Academic Article	A Protein in the Yeast Saccharomyces cerevisiae Presents DNA Binding Homology to the p53 Checkpoint Protein and Tumor Suppressor.
Academic Article	Gain-of-function mutant p53: history and speculation.
Academic Article	Multiple roles of the tumor suppressor p53.
Academic Article	In vivo footprinting and DNA affinity chromatography for analysis of p53 DNA binding ability.
Academic Article	Wild-type p53 activates transcription in vitro.
Academic Article	Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.
Academic Article	Mutant p53 forms a complex with Sp1 on HIV-LTR DNA.
Academic Article	Camptothecin and Zeocin can increase p53 levels during all cell cycle stages.
Academic Article	Differential activation of p53 by the various adducts of mitomycin C.
Academic Article	Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta.
Academic Article	Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication.
Academic Article	Phospholipase D elevates the level of MDM2 and suppresses DNA damage-induced increases in p53.
Academic Article	A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.
Academic Article	Functional consequences of the interactions of the p53 tumor suppressor protein and SV40 large tumor antigen.
Academic Article	A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.
Academic Article	Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription.
Academic Article	Mutant p53 in MDA-MB-231 breast cancer cells is stabilized by elevated phospholipase D activity and contributes to survival signals generated by phospholipase D.
Academic Article	Mitomycin-DNA adducts induce p53-dependent and p53-independent cell death pathways.
Academic Article	Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes.
Academic Article	p53 represses Sp1 DNA binding and HIV-LTR directed transcription.
Concept	Protein Binding
Concept	Protein Conformation
Concept	Protein Kinase C
Concept	Protein Kinases
Concept	Protein Processing, Post-Translational
Concept	Protein Biosynthesis
Concept	Tumor Suppressor Protein p53
Concept	Retinoblastoma Protein
Concept	CDC2 Protein Kinase
Concept	BRCA1 Protein
Concept	Protein Isoforms
Concept	Mitogen-Activated Protein Kinases
Concept	Protein Transport
Concept	Protein Footprinting
Concept	BRCA2 Protein
Concept	Protein Kinase Inhibitors
Concept	p38 Mitogen-Activated Protein Kinases
Concept	Protein Kinase C-delta
Concept	Protein Stability
Academic Article	Targeting Triple Negative Breast Cancer with a Nucleus-Directed p53 Tetramerization Domain Peptide.
Academic Article	PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models.
Academic Article	The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose.
Academic Article	Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
Academic Article	p53 suppresses MHC class II presentation by intestinal epithelium to protect against radiation-induced gastrointestinal syndrome.

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